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Article Dans Une Revue Environment International Année : 2021

Early-life environmental exposure determinants of child behavior in Europe: A longitudinal, population-based study

1 ISGlobal - Instituto de Salud Global - Institute For Global Health [Barcelona]
2 UPF - Universitat Pompeu Fabra [Barcelona]
3 CIBERESP - Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública = Consortium for Biomedical Research of Epidemiology and Public Health
4 Institut d’Investigacio Sanitaria Pere Virgili (IISPV), Hospital Universitari Sant Joan de Reus, Reus,
5 Division of Immunology and Immunotherapy, Cima Universidad de Navarra and “Instituto de Investigaci´on Sanitaria de Navarra (IdISNA)", Pamplona,
6 INSERM, Univ. Grenoble Alpes, CNRS, IAB (Institute of Advanced Biosciences), Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, Grenoble,
7 NIPH - Norwegian Institute of Public Health [Oslo]
8 Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Centre-Sophia Children’s Hospital, PO Box 2060, 3000 CB, Rotterdam,
9 Vytauto Didziojo Universitetas (VDU), Kaunas,
10 Department of Preventive Medicine, Keck School of Medicine at USC, Los Angeles,
11 Universit´e de Paris, Center for Research in Epidemiology and StatisticS (CRESS), INSERM, INRA, F-75004 Paris,
12 Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion
13 Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford Royal Infirmary, Bradford
14 MRC-PHE Centre for Environment and Health, Dept of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London

Résumé

Background: Environmental exposures in early life influence the development of behavioral outcomes in children, but research has not considered multiple exposures. We therefore aimed to investigate the impact of a broad spectrum of pre- and postnatal environmental exposures on child behavior. Methods and findings: We used data from the HELIX (Human Early Life Exposome) project, which was based on six longitudinal population-based birth cohorts in Europe. At 6–11 years, children underwent a follow-up to characterize their exposures and assess behavioral problems. We measured 88 prenatal and 123 childhood environmental factors, including outdoor, indoor, chemical, lifestyle and social exposures. Parent-reported behavioral problems included (1) internalizing, (2) externalizing scores, using the child behavior checklist (CBCL), and (3) the Conner’s Attention Deficit Hyperactivity Disorder (ADHD) index, all outcomes being discrete raw counts. We applied LASSO penalized negative binomial regression models to identify which exposures were associated with the outcomes, while adjusting for co-exposures. In the 1287 children (mean age 8.0 years), 7.3% had a neuropsychiatric medical diagnosis according to parent’s reports. During pregnancy, smoking and car traffic showing the strongest associations (e.g. smoking with ADHD index, aMR:1.31 [1.09; 1.59]) among the 13 exposures selected by LASSO, for at least one of the outcomes. During childhood, longer sleep duration, healthy diet and higher family social capital were associated with reduced scores whereas higher exposure to lead, copper, indoor air pollution, unhealthy diet were associated with increased scores. Unexpected decreases in behavioral scores were found with polychlorinated biphenyls (PCBs) and organophosphate (OP) pesticides. Conclusions: Our systematic exposome approach identified several environmental contaminants and healthy lifestyle habits that may influence behavioral problems in children. Modifying environmental exposures early in life may limit lifetime mental health risk.
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hal-04651968 , version 1 (17-07-2024)

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Léa Maitre, Jordi Julvez, Monica López-Vicente, Charline Warembourg, Ibon Tamayo-Uria, et al.. Early-life environmental exposure determinants of child behavior in Europe: A longitudinal, population-based study. Environment International, 2021, 153, pp.106523. ⟨10.1016/j.envint.2021.106523⟩. ⟨hal-04651968⟩

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