In this paper we present our study (n = 30) to gauge the effect of hand-dominance on Fitts’ throughput through four test cases—forefingers and thumbs of dominant and non-dominant hands in tapping tasks for touch-based mobile interfaces. We set out with the expectation that throughput for a dominant digit would exceed that for the corresponding digit of the other hand. We reveal that this was followed in the case of right-handed users for both forefingers and thumbs, and in case of forefingers for all users. Right-handed users had higher throughput for dominant digits (mean = 5.608) than non-dominant digits (mean = 4.736). All users had higher throughput for dominant forefingers (mean = 6.081) than non-dominant forefingers (mean = 5.436). However, surprisingly, left-handed users showed a higher throughput for non-dominant thumbs (mean = 6.078) than dominant thumbs (mean = 5.721). Throughputs of forefingers and thumbs were not significantly different for any groups.