Even within the financial crisis Global Sourcing is gaining more and more importance. Although a lot of European companies have already a long experience with international supply markets, uncertainties about the consequences and the costs related to a specific international supplier selection still remain. The Total Cost of Ownership concept is an interesting approach in order to cope with this problem. In the present paper key requirements for a Total Cost of Ownership concept from an industrial perspective are described. In the following, a Total Cost of Ownership concept is presented which allows conducting detailed Total Cost of Ownership calculations structured in different key modules. These key modules base on macroeconomic and microeconomic aspects which can also be largely used independently.