Modern Out-of-Order (OoO) CPUs are complex systems with many components interleaved in non-trivial ways. Pinpointing performance bottlenecks and understanding the underlying causes of program performance issues are critical tasks to make the most of hardware resources. We provide an in-depth overview of performance bottlenecks in recent OoO microarchitectures and describe the difficulties of detecting them. Techniques that measure resources utilization can offer a good understanding of a program's execution, but, due to the constraints inherent to Performance Monitoring Units (PMU) of CPUs, do not provide the relevant metrics for each use case. Another approach is to rely on a performance model to simulate the CPU behavior. Such a model makes it possible to implement any new microarchitecture-related metric. Within this framework, we advocate for implementing modeled resources as parameters that can be varied at will to reveal performance bottlenecks. This allows a generalization of bottleneck analysis that we call sensitivity analysis. We present Gus, a novel performance analysis tool that combines the advantages of sensitivity analysis and dynamic binary instrumentation within a resource-centric CPU model. We evaluate the impact of sensitivity on bottleneck analysis over a set of high-performance computing kernels.