Deduplication of primary storage volumes in a cloud computing environment is increasingly desirable, as the resulting space savings contribute to the cost effectiveness of a large scale multi-tenant infrastructure. However, traditional archival and backup deduplication systems impose prohibitive overhead for latency-sensitive applications deployed at these infrastructures while, current primary deduplication systems rely on special cluster filesystems, centralized components, or restrictive workload assumptions.We present DEDIS, a fully-distributed and dependable system that performs exact and cluster-wide background deduplication of primary storage. DEDIS does not depend on data locality and works on top of any unsophisticated storage backend, centralized or distributed, that exports a basic shared block device interface. The evaluation of an open-source prototype shows that DEDIS scales out and adds negligible overhead even when deduplication and intensive storage I/O run simultaneously.