This panel discusses the role of human-computer interaction (HCI) in the conception, design, and implementation of human-centered artificial intelligence (AI). For us, it is important that AI and machine learning (ML) are ethical and create value for humans-as individuals as well as for society. Our discussion emphasizes the opportunities of using HCI and User Experience Design methods to create advanced AI/MLbased systems that will be widely adopted, reliable, safe, trustworthy, and responsible. The resulting systems will integrate AI and ML algorithms while providing user interfaces and control panels that ensure meaningful human control.