Today Enterprise Interoperability is considered as a key factor of successful collaboration. It was identified as a critical need that has to be taken into account all along the lifecycle of a manufactured product. To deal with this problem and to reduce complexity of the different systems of interest used when different companies have to collaborate together, Enterprise Architecture (EA) and Enterprise Modelling (EM) are considered as solutions to facilitate Enterprise Interoperability. Dealing with interoperability issues in the context of Product Lifecycle Management (PLM), we have to mention the importance of product data and process standards implementation as interoperability enablers. In order to address the complexity of PLM standards, we propose to apply a model-driven methodology for modelling these standards and the related collaboration scenarios. This approach intends to make standards more comprehensive and to better manage standards evolutions, but also to instantiate and re-use these “generic” standards models to specify specific business collaboration scenarios. This proposal aims also to facilitate the exchange, testing and simulation of standards implementations. In this paper, the focus is on the ISA 95 standard for manufacturing-PLM integration, with an exchange scenario between Enterprise Resource Planning (ERP) and Manufacturing Execution System (MES) based on ISA 95 standard.