Collecting relevant and appropriate data when conducting research in the Global South and other resource-constrained environments can be challenging. This is particularly true when the researcher originates from a different country and has different social, cultural, and political beliefs to the research participants. Data collection in such contexts can be challenging for a variety of ethical, philosophical, theoretical, and methodological reasons which may arise resulting from the use of research approaches designed in the Global North. There are also many practical and infrastructural issues which may be relevant in resource-constrained countries. This paper provides examples of challenges encountered by the authors in a variety of ongoing research projects in the Global South. We propose approaches to address the identified challenges, and we conclude by calling for additional work on this important topic.