There are several benefits reported in the literature regarding the Lean approach and Industry 4.0 integration. In general, the most significant justification for integrating these two concepts is that incorporating new technologies in a production system should only occur once the system is operating without waste and in an optimized way. Thus, implementing the Lean approach represents an excellent opportunity for organizations that want to use the technologies of Industry 4.0 (I4.0). Although Industry 4.0 brings new opportunities for digitalizing production systems, machines and equipment cannot suggest improvements independently. In this way, employees will continue to be an integral part of production systems. However, when analyzing the specialized literature, it was possible to observe that the discussion about workers’ participation to effectively implement the new technologies of I4.0 in the productive systems is incipient. Thus, this work presents a new framework developed called Systematic for Process Improvement Using Cyber-Physical Systems and Toyota Kata that use the Improvement Kata and Coaching Kata routines and the cadence of activities from the training of employees to the development of the Cyber-Physical System of the organization to implement the new technologies of Industry 4.0. The systematic was tested in a theoretical case study, and the results showed that it was possible to develop a Cyber-Physical System using SIMIO® software. Improvements could be developed and simulated in the digital environment with data from the actual process.