Digital Twins (DT) represent one of the most powerful technologies related to Industry 4.0 implementation. Combined with the advances in Computer Science and Production Management, DTs have become an emerging trend in many applications. Despite the DT potentials, Industry 4.0 is pushing companies to adopt digital solutions that provide higher human satisfaction to increase operational excellence. One approach to handle this involves how workers should interact with systems and smart machines. Softbots is a prominent direction to underpin this goal. This paper presents ongoing results of a research that exploits how softbots can be combined with DTs to create a more “symbiotic” human-machine/computer interaction within a smarter decision-making environment.