Industry 4.0 has become a centerpiece of strategic plans and national policies in many countries. Studies have pointed out the many obstacles for the adoption of Industry 4.0 in larger scale towards such strategic plans, including the lack of skilled people and the low level of companies’ innovation. Triple-helix-based innovation models have been proposed to reinforce collaboration between different actors, and it is reasonably clear nowadays “what to do”. However, the “how to do” is not so trivial, considering the so many existing differences from region to region, intheir culture, and in companies’ Industry 4.0 maturity levels. Relying on collaborative networks foundations, this paper presents a framework as a contribution to make those actors working together more effectively and systematically in way to mitigate some of those obstacles. This framework has been gradually implemented during the last two years. This paper presents the framework itself and its main results so far achieved.