Digitalization and Industry 4.0 continue to shape our industrial environment and collaboration. For many enterprises,a key challenge in moving forward in this matter is the integration of their shop-floor systems (hard-and software) with their office-floor systems to harvest the full potential of industry 4.0. A multitude of different technologies and respective use-cases availableon the market leave many companies startled. This paper presents a set of use-cases for IT-OT-Integration to bring transparency into a company’s digital transformation. Additionally, a technical requirements profile for integrating IT-and OT-Systems based on the use cases is presented. Both, use-cases and their requirements, guide companies in selecting the digitalization measures that fit their current situation and help in identifying technical challenges that need to be addressed in the transformation process.