Artificial intelligence (AI) has become an integral element of modern machines, devices and materials, and already transforms the way humans interact with technology in business and society. The traditionally more hierarchical interaction, where humans usually control machines, is constantly blurring as machines become more capable of bringing in their own (intelligent) initiatives to the interaction with humans. Thus, nowadays it is more appropriate to consider the interactive processes between humans and machines as a novel form of interdependent learning efforts between both sides, where processes such as critical discourses between humans and machines may take place (hybrid intelligence). However, these developments demand a shift in the understanding about the role of technology at work and about specific competencies required among human actors to collaborate constructively and sustainably with AI systems. This paper seeks to address this issue by identifying human actors’ key competencies, which enable a more constructive collaboration between humans and intelligent technologies at work.