Knowledge graphs (KG) as emerging technology contribute to knowledge networking and efficient knowledge collaboration. Sound knowledge about why organizations should develop KGs and how they can make and use KG is the key to success. However, the organized work on the Make and Use of KG can be perceived as another kind of highly collaborative activities between organizations, people, machines and systems, which received few attentions in research. Thus, we adopt socio-technical systems (STS) perspective to review, practice and study how to effectively make and use KGs through collaborative activities. This study reveals a collaborative-activity framework of KG’s Make and Use and corresponding collaborative mechanisms, which may contribute to the existing literature of KG/AI, knowledge collaborative networks and STS. Organizations can use this framework to develop their own domain-specific KG and KG-based information.