Developing countries have numerous challenges to manage in terms of supply chain and logistics networks such as safety, corruption, pollution, congestion, old and/or unsuitable vehicles, long lead times, economy, wastes and of course poor infrastructures and so on. While developed countries have started to change their mindset and toolboxes for managing their material flows all along their logistics networks, it is not yet the case for developing countries. This research work intends to study potentials benefit for these countries if there are drastic changes of the way physical of material flows are managed. In such a context, Physical Internet paradigm is considered as an interesting avenue for improvement. The objective of this paper is to draft an options that would be necessary to assess and to design the associated research methodology. Insights regarding an ongoing field-oriented research work in Cambodia are developed to highlight the potential.