The production and distribution of counterfeited products is an issue for decades in different industry sectors. The trade in fake goods is growing and is affecting the sales and profits of the companies exposed to this phenomenon. It influences governments, world trade, businesses, and consumers, by reducing revenues, economic growth, and consumers’ health. This paper aims to present a proposed system for restriction of product counterfeit. This system will be applied in the supply chain of goods, including operations like production, distribution, and sales. In order to ensure the identification and traceability of genuine products throughout the supply chain, the blockchain technology and secure marking techniques of the products will be used. The paper presents the conceptual design of the system, its functionality, the methodological approach for its development and its application in selected industry sectors, as well as the expected results by its use in the supply chain of products.