The function or department of production control in manufacturing companies deals with short-term scheduling of orders and the management of deviations during order execution. Depending on the equipment and characteristics of orders, sequence dependent setup times might occur. In these cases for companies that focus on high utilization of their assets due to long phases of ramp up and high energy costs, it might be optimal to choose sequences with minimal setup time times between orders. Identifying such sequences requires detailed and correct information regarding the specific setup times. With increasing product variety and shorter lot sizes, it becomes more difficult and rather time intense to determine these values manually. One approach is to analyse the relevant features of the orders described in the route sheets or recipes to find similarities in materials and required tools. This paper presents a methodology, which supports setup optimized sequencing for sequence dependent setup times through constructing the setup matrix from such route sheets with the use of data analytics.