The aim of this paper is concerned with a conceptual framework to get about the smart factory concept in the mould/tools industry, by retrieving knowledge from historical data and data analysis. Specifically, it will be addressed the requirements to design and develop the next generation of open decision making informatics systems as tools for high variability manufacturing systems as in the tooling industry. The proposed open computational platform as open informatics systems (I-systems) developed under the specifications of the conceptual framework mention above will combine new balancing and simulation algorithms that allow the optimization of the production systems suggesting new and credible collaborative production sequences in a forecasting manner. Coupling smart monitoring with real-time decision support I-systems, the proposed approach will be able to cope with the aim of reducing lead-times and costs on the shop floor. The proposed open system of systems approach aims at contributing to adaptive higher integration levels, contribute for a collaborative factory and, at the same time, reduce the vendor lock-in dependencies risks.