This article concerns with human-computer-interaction (HCI) from a neuroscientific perspective. The motivation for this perspective is the demographic transition, which shifts population structures of industrial nations. The authors will explain consequences of the demographic transition in terms of HCI and establish a hypothesis for these research activities. To evaluate this hypothesis the authors develop an approach, which combines different disciplines. This approach examines the effects of IT-accessibility on human cognitive processing. Therefore, required methodologies and instruments will be explained, discussed and selected. Possible effects of IT-accessibility on human cognitive processing will be illustrated with an acknowledged cognition model. The result of this article will be a concept, which enables the measurement of IT-accessibility impacts on human cognitive processing.