Enterprises today face many challenges related to lack of interoperability. But several business and technical solutions are available to bridge this gap. This paper presents a structured and tooled methodology to help decision-makers to quantitatively assess interoperability solutions for their networked enterprise. Practically, this research work proposes an a priori performance measurement system that is able to model and simulate different interoperability solutions. Through a bi-dimensional analysis (stakes and accessibility), the system allows comparing all the potential solutions in order to choose the best one for the network. This scientific proposition is finally implemented on a real application case extracted from the French ISTA3 research project.