Article Dans Une Revue Beilstein Journal of Organic Chemistry Année : 2024

Multicomponent synthesis of α-branched amines using organozinc reagents generated from alkyl bromides

Résumé

The use of alkylzinc bromides in the multicomponent Mannich reaction is described. Heteroleptic organozinc compounds were obtained in THF or 2-MeTHF by direct insertion of zinc dust into the C-Br bond of alkyl bromides. It was found that the presence of a stoichiometric amount of LiCl was essential for the efficiency of the subsequent three-component coupling with aldehydes and amines. A variety of primary, secondary, and tertiary organozinc reagents as well as secondary amines and aromatic aldehydes could be used for the straightforward preparation of α-branched amines. Interestingly, whereas previously reported work describing the preparation and reaction of organozinc iodides in acetonitrile showed higher reactivity of secondary organozinc reagents over primary ones, reactions in THF in the presence of LiCl led to opposite results, with higher reactivity of primary organozinc reagents.

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Chimie
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hal-04911206 , version 1 (24-01-2025)

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Baptiste Leroux, Alexis Beaufils, Federico Banchini, Olivier Jackowski, Alejandro Perez-Luna, et al.. Multicomponent synthesis of α-branched amines using organozinc reagents generated from alkyl bromides. Beilstein Journal of Organic Chemistry, 2024, 20, pp.2834 - 2839. ⟨10.3762/bjoc.20.239⟩. ⟨hal-04911206⟩
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